USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: P00354 USC-OGP 2-DE database:  P00354 P00354 General information about the entry View entry in simple text format Entry name G3P_HUMAN Primary accession number P00354 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Glyceraldehyde-3-phosphate dehydrogenase; Short=GAPDH; EC=1.2.1.12; AltName: Full=Peptidyl-cysteine S-nitrosylase GAPDH; EC=2.6.99.-;. Gene name Name=GAPDH Synonyms=GAPD ORFNames=CDABP0047, OK/SW-cl.12 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein PLATELET_6-11 {PLATELET 6-11} Homo sapiens (Human)   map experimental info   PLATELET_6-11 MAP LOCATIONS: SPOT OGP-0977: pI=8.40; Mw=35553 UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1223: pI=6.07; Mw=35353 SPOT OGP-1225: pI=7.94; Mw=35254 SPOT OGP-1356: pI=6.29; Mw=13093 Cross-references UniProtKB/Swiss-Prot P04406; G3P_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name G3P_HUMAN Primary accession number P04406 Secondary accession number(s) E7EUT4 P00354 Q53X65 Sequence was last modified on  January 23, 2007 (version 3) Annotations were last modified on  March 15, 2017 (version 222) Name and origin of the protein Description RecName: Full=Glyceraldehyde-3-phosphate dehydrogenase; Short=GAPDH; EC=1.2.1.12; AltName: Full=Peptidyl-cysteine S-nitrosylase GAPDH; EC=2.6.99.-; Gene name Name=GAPDH Synonyms=GAPD ORFNames=CDABP0047, OK/SW-cl.12 Encoded on Name=GAPDH; Synonyms=GAPD; ORFNames=CDABP0047, OK/SW-cl.12 Keywords 3D-structure; Acetylation; ADP-ribosylation; Alternative splicing; Apoptosis; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; Glycolysis; Membrane; Methylation; NAD; Nucleus; Oxidation; Oxidoreductase; Phosphoprotein; Polymorphism; Reference proteome; S-nitrosylation; Transferase; Translation regulation; Ubl conjugation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL X01677; CAA25833.1; -; mRNA EMBL M17851; AAA86283.1; -; mRNA EMBL M33197; AAA52518.1; -; mRNA EMBL J02642; AAA52496.1; -; mRNA EMBL J04038; AAA53191.1; -; Genomic_DNA EMBL X53778; CAA37794.1; -; mRNA EMBL AF261085; AAF99678.1; -; mRNA EMBL AY007133; AAG01996.1; -; mRNA EMBL AB062273; BAB93466.1; -; mRNA EMBL BT006893; AAP35539.1; -; mRNA EMBL AY340484; AAP88932.1; -; Genomic_DNA EMBL CR407671; CAG28599.1; -; mRNA EMBL AC006064; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471116; EAW88787.1; -; Genomic_DNA EMBL BC001601; AAH01601.1; -; mRNA EMBL BC004109; AAH04109.1; -; mRNA EMBL BC009081; AAH09081.1; -; mRNA EMBL BC013310; AAH13310.1; -; mRNA EMBL BC023632; AAH23632.1; -; mRNA EMBL BC025925; AAH25925.1; -; mRNA EMBL BC026907; AAH26907.1; -; mRNA EMBL BC029618; AAH29618.1; -; mRNA EMBL BC083511; AAH83511.1; -; mRNA CCDS CCDS58201.1; -. [P04406-2]; . CCDS CCDS8549.1; -. [P04406-1]; . PIR A31988; DEHUG3; . RefSeq NP_001243728.1; NM_001256799.2. [P04406-2]; . RefSeq NP_001276674.1; NM_001289745.1. [P04406-1]; . RefSeq NP_001276675.1; NM_001289746.1. [P04406-1]; . RefSeq NP_002037.2; NM_002046.5. [P04406-1]; . UniGene Hs.544577; -; . UniGene Hs.592355; -; . UniGene Hs.598320; -; . PDB 1U8F; X-ray; 1.75 A; O/P/Q/R=1-335 PDB 1ZNQ; X-ray; 2.50 A; O/P/Q/R=1-335 PDB 2FEH; Model; -; O/P/Q/R=1-335 PDB 3GPD; X-ray; 3.50 A; G/R=2-335 PDB 4WNC; X-ray; 1.99 A; A/B/C/D/E/F/G/O=1-335 PDB 4WNI; X-ray; 2.30 A; A/B/C/O=1-335 PDBsum 1U8F; -; . PDBsum 1ZNQ; -; . PDBsum 2FEH; -; . PDBsum 3GPD; -; . PDBsum 4WNC; -; . PDBsum 4WNI; -; . ProteinModelPortal P04406; -; . SMR P04406; -; . BioGrid 108868; 202; . DIP DIP-32521N; -; . IntAct P04406; 94; . MINT MINT-1150338; -; . STRING 9606.ENSP00000229239; -; . BindingDB P04406; -; . ChEMBL CHEMBL2284; -; . DrugBank DB07347; 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE; . DrugBank DB02059; Adenosine-5-Diphosphoribose; . DrugBank DB00157; NADH; . DrugBank DB03893; Thionicotinamide-Adenine-Dinucleotide; . iPTMnet P04406; -; . PhosphoSitePlus P04406; -; . SwissPalm P04406; -; . BioMuta GAPDH; -; . DMDM 120649; -; . DOSAC-COBS-2DPAGE P04406; -; . OGP P04406; -; . REPRODUCTION-2DPAGE IPI00219018; -; . REPRODUCTION-2DPAGE P04406; -; . SWISS-2DPAGE P04406; -; . UCD-2DPAGE P04406; -; . EPD P04406; -; . PaxDb P04406; -; . PeptideAtlas P04406; -; . PRIDE P04406; -; . TopDownProteomics P04406-1; -. [P04406-1]; . DNASU 2597; -; . Ensembl ENST00000229239; ENSP00000229239; ENSG00000111640. [P04406-1]; . Ensembl ENST00000396858; ENSP00000380067; ENSG00000111640. [P04406-2]; . Ensembl ENST00000396859; ENSP00000380068; ENSG00000111640. [P04406-1]; . Ensembl ENST00000396861; ENSP00000380070; ENSG00000111640. [P04406-1]; . Ensembl ENST00000619601; ENSP00000478864; ENSG00000111640. [P04406-2]; . GeneID 2597; -; . KEGG hsa:2597; -; . UCSC uc031qfw.3; human. [P04406-1]; . CTD 2597; -; . DisGeNET 2597; -; . GeneCards GAPDH; -; . H-InvDB HIX0000949; -; . H-InvDB HIX0024996; -; . HGNC HGNC:4141; GAPDH; . HPA CAB005197; -; . HPA CAB016392; -; . HPA HPA040067; -; . HPA HPA061280; -; . MIM 138400; gene; . neXtProt NX_P04406; -; . OpenTargets ENSG00000111640; -; . PharmGKB PA28554; -; . eggNOG KOG0657; Eukaryota; . eggNOG COG0057; LUCA; . GeneTree ENSGT00760000119172; -; . HOGENOM HOG000071678; -; . HOVERGEN HBG000227; -; . InParanoid P04406; -; . KO K00134; -; . OMA KWGEVGA; -; . OrthoDB EOG091G0B1Y; -; . PhylomeDB P04406; -; . TreeFam TF300533; -; . BioCyc MetaCyc:HS03433-MONOMER; -; . BRENDA 1.2.1.12; 2681; . Reactome R-HSA-70171; Glycolysis; . Reactome R-HSA-70263; Gluconeogenesis; . SABIO-RK P04406; -; . UniPathway UPA00109; UER00184; . ChiTaRS GAPDH; human; . EvolutionaryTrace P04406; -; . GeneWiki Glyceraldehyde_3-phosphate_dehydrogenase; -; . GenomeRNAi 2597; -; . PRO PR:P04406; -; . Proteomes UP000005640; Chromosome 12; . Bgee ENSG00000111640; -; . CleanEx HS_GAPDH; -; . ExpressionAtlas P04406; baseline and differential; . Genevisible P04406; HS; . GO GO:0005737; C:cytoplasm; ISS:UniProtKB; . GO GO:0005829; C:cytosol; ISS:UniProtKB; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0031012; C:extracellular matrix; IDA:BHF-UCL; . GO GO:0097452; C:GAIT complex; IDA:UniProtKB; . GO GO:0043231; C:intracellular membrane-bounded organelle; IDA:HPA; . GO GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB; . GO GO:0005811; C:lipid particle; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0015630; C:microtubule cytoskeleton; ISS:UniProtKB; . GO GO:0031965; C:nuclear membrane; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:UniProtKB; . GO GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell; . GO GO:0005886; C:plasma membrane; IDA:HPA; . GO GO:0031982; C:vesicle; IDA:UniProtKB; . GO GO:0004365; F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity; ISS:UniProtKB; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0008017; F:microtubule binding; ISS:UniProtKB; . GO GO:0051287; F:NAD binding; IEA:InterPro; . GO GO:0050661; F:NADP binding; IEA:InterPro; . GO GO:0035605; F:peptidyl-cysteine S-nitrosylase activity; ISS:UniProtKB; . GO GO:0061621; P:canonical glycolysis; TAS:Reactome; . GO GO:0071346; P:cellular response to interferon-gamma; IDA:UniProtKB; . GO GO:0006094; P:gluconeogenesis; TAS:Reactome; . GO GO:0000226; P:microtubule cytoskeleton organization; ISS:UniProtKB; . GO GO:0017148; P:negative regulation of translation; IDA:UniProtKB; . GO GO:0051402; P:neuron apoptotic process; ISS:UniProtKB; . GO GO:0035606; P:peptidyl-cysteine S-trans-nitrosylation; ISS:UniProtKB; . GO GO:0050821; P:protein stabilization; ISS:UniProtKB; . GO GO:0016241; P:regulation of macroautophagy; TAS:ParkinsonsUK-UCL; . Gene3D 3.40.50.720; -; 1; . InterPro IPR020831; GlycerAld/Erythrose_P_DH; . InterPro IPR020830; GlycerAld_3-P_DH_AS; . InterPro IPR020829; GlycerAld_3-P_DH_cat; . InterPro IPR020828; GlycerAld_3-P_DH_NAD(P)-bd; . InterPro IPR006424; Glyceraldehyde-3-P_DH_1; . InterPro IPR016040; NAD(P)-bd_dom; . PANTHER PTHR10836; PTHR10836; 1; . Pfam PF02800; Gp_dh_C; 1; . Pfam PF00044; Gp_dh_N; 1; . PIRSF PIRSF000149; GAP_DH; 1; . PRINTS PR00078; G3PDHDRGNASE; . SMART SM00846; Gp_dh_N; 1; . SUPFAM SSF51735; SSF51735; 1; . TIGRFAMs TIGR01534; GAPDH-I; 1; . PROSITE PS00071; GAPDH; 1; .

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